Additionally, HOXC10 binds to Ku70, a protein coded by X-ray repair cross complementing 6 (XRCC6) gene and is essential for DNA repair, and accelerates the DNA repair through the non-homologous end-joining (NHEJ) pathway, a pivotal pathway repairs DNA damage caused by radiation and chemotherapy, indicating that elevated HOXC10 levels in patients with ESCC may predict poorer outcomes following radiation or chemotherapy.9 Here, XRCC6 is linked to esophageal squamous cell carcinoma.