,56 In hepatocellular carcinoma, RNA-binding motif protein 15 (RBM15) and ALKBH5 regulate the recruitment of programmed death-ligand 1-positive (PD-L1+) macrophages via C-X-C motif chemokine ligand 11 (CXCL11) and mitogen-activated protein kinase 8 (MAP3K8) pathways, facilitating the formation of immunosuppressive microenvironments.57 The gene discussed is MAP3K8; the disease is hepatocellular carcinoma.