In lung cancer models, ALKBH5 regulates the circRNA echinoderm microtubule-associated protein-like 4 (circEML4)/miRNA/suppressor of cytokine signaling 2 (SOCS2) axis, supporting the M2-like function of tumor-associated macrophages and facilitating immune evasion in non-small cell lung cancer.47 This evidence concerns the gene SOCS2 and non-small cell lung carcinoma.