GBP4 and injury: YTHDF1 can facilitate the translation of guanylate binding protein 4 (GBP4), promoting M1 polarization in acute lung injury,51 while m6A-regulated circRNA-miRNA axes, such as circ_0066715/miR-486-5p/ETS proto-oncogene 1 (ETS1) axis, are closely associated with M2 polarization in rheumatoid arthritis.52