ME2 and ovarian carcinoma: Recent studies have suggested that lactate derived from aerobic glycolysis contributes a lot to chemotherapy resistance.109, 110, 111 In ovarian cancer, chemotherapy impairs glucose uptake and decreases the intracellular glucose level, which triggers the acetylation of ME2 at lysine 156 by ACAT1, leading to increased ME2 enzyme activity and facilitating the production of lactate from glutamine.112