AKT1 and cancer: Furthermore, Biological Process enrichment analysis revealed important involvement of GbPDTO DEGs in cancer-related pathways, including “positive regulation of cell population proliferation”, “response to hypoxia”, “negative regulation of apoptotic process”, “angiogenesis”, “epidermal growth factor receptor signaling pathway”, and “positive regulation of PI3K/AKT signal transduction” (Fig. 3G).