Kyoto Encyclopedia of Genes and Genomes pathway enrichment analysis identified key oncogenic and tumor-progression-related signaling pathways associated with the DEGs, including “MAPK signaling”, “transcriptional misregulation in cancer”, “cellular senescence”, “TNF signaling pathway”, “proteoglycans in cancer”, and “Ras signaling pathway” (Fig. 3E) [27–29]. Here, TNF is linked to cancer.