Based on previous studies that the VPS35 D620N mutation has been found to regulate the fate of neural stem cells and the role of neurogenesis in the pathogenesis of PD (Qiu et al., 2024; Appel et al., 2018), this study aims to explore the potential mechanism of the VPS35 D620N mutant on neurogenesis through experiment and bioinformatics methods. Here, VPS35 is linked to Parkinson disease.