In the context of PD, the PI3K-Akt signaling pathway has been demonstrated to possess neuroprotective properties by mitigating neurotoxicity, thus promoting the survival and maturation of neuronal populations in critical brain regions such as the hippocampus and substantia nigra pars compacta (Yang et al., 2021; Luo et al., 2019). The gene discussed is AKT1; the disease is Parkinson disease.