However, indicators directly associated with neurosyphilis diagnosis (serum TRUST titers and CSF NTTs) and indicators reflecting intrathecal humoral immune activation and BBB impairment (CSF albumin, CSF IgG, IgG quotient, albumin quotient, IgG index, and IgG synthesis rate) exhibited significant interclass variations (P<0.001). The gene discussed is ALB; the disease is neurosyphilis.