These patients exhibit normal CSF protein (<0.5 g/L) and nucleated cell counts (<5×106/L), with lower serum TRUST titers (<1:16) and distinct CSF immunological profiles (albumin quotient, IgG synthesis rate, IgG index) compared to typical neurosyphilis (P < 0.05) yet evidence of intrathecal antibody synthesis, suggests a distinct host-pathogen interaction. This evidence concerns the gene ALB and neurosyphilis.