In addition, studies have shown that the levels of CSF protein and white blood cell count are positively correlated with the inflammatory markers CXCL13, IL-6, and IL-10, which suggests that patients with atypical neurosyphilis may not have a significant or active inflammatory response (Dersch et al., 2015; Yan et al., 2017). This evidence concerns the gene CXCL13 and neurosyphilis.