Furthermore, in patients with sepsis caused by gram-negative bacteria, Panx1 expression in the donor liver was significantly reduced, leading to decreased IL-33 release through the inhibition of the P2X7/NLRP3 signaling pathway, which reduced the proliferation and differentiation capacity of ST2+ Treg cells, increasing the incidence and mortality of sepsis after LT (Wang P. et al., 2022). This evidence concerns the gene P2RX7 and Sepsis.