Jiang et al. (2024) demonstrated that myxoma cells exhibit a fibroblast-like transcriptional program, while tumor-associated macrophages expressing growth-promoting and angiogenic mediators (e.g., PDGFC, EREG) interact with fibroblasts enriched in extracellular matrix-modifying genes (e.g., POSTN, COL1A family), collectively supporting stromal remodeling, fibrosis, and T-cell dysfunction [19]. The gene discussed is POSTN; the disease is myxoma.