Transplantation of ADSCs attenuates PAH progression in a MCT-induced rat model, which may involve six dysregulated microRNAs (miR-133a-3p,miR-206, miR-200a-3p, miR-141-3p, miR-1246 and miR-537) in ADSCs, They improve pulmonary vascular endothelial remodeling by regulating multiple signaling pathways, including Wnt, VEGF, cytokine-cytokine receptor interactions, mitogen-activated protein kinase, actin cytoskeleton regulation, TGF-β, and p53 signaling cascades (Wang et al., 2019b). The gene discussed is VEGFA; the disease is pulmonary arterial hypertension.