Conversely, a recent retrospective multicenter cohort study that analyzed electronic health records of 113 million US patients found that the risk of thyroid cancer did not differ among patients exposed to GLP-1RA compared to those exposed to insulin, whereas GLP-1RA decreased the risk of 10 other cancers including pancreatic cancer, ovarian cancer, colorectal cancer, and others [33]. Here, INS is linked to colorectal cancer.