NLRP3 and lobular neoplasia: In renal tissues from LN patients and nephritic MRL/lpr mice, the sodium-glucose cotransporter 2 (SGLT2) inhibitor empagliflozin attenuated proteinuria by enhancing autophagy to preserve cellular homeostasis and suppressing NLRP3 inflammasome activation, highlighting the need for further investigation into the renoprotective mechanisms of SGLT2 inhibitors in LN (206).