SQSTM1 and cholelithiasis: Using PheWAS Portal and PheWeb databases, we performed full phenomenon Mendelian randomization to determine possible side effects of targeting DLD, NFE2L2, SDHB, SLC2A1, PSAT1, SQSTM1. It was found that, as shown in the PheWeb database (Table 7), The gene DLD is associated with Cholelithiasis and cholecystitis, Cholelithiasis, Inflammatory bowel disease and gastroenteritis and colitis other gastroenteritis and colitis), Ulcerative colitis, and the NFE2L2 gene with Abnormal sputum p value < 5 × 10–8), Hemoptysis (p value < 5 × 10–8) at the genome-wide significance level.