Other subtypes found in higher percentages in ACPA/+ patients were CD19+ B cells (91); and for patients with early RA, human leukocyte antigen (HLA)-DR+-peripheral type helper T cells, PD-1hi CD8+ T cells, CXCR5− CD11c− CD38+ naive B cells (98) and CD19+ CD24hi CD38hi regulatory B cells (99). Here, CXCR5 is linked to rheumatoid arthritis.