CEL-4000 was tested in PG-induced arthritis (PGIA) and G1 domain-induced arthritis (GIA) mice models, switching cytokine production from Th1 and Th17 pro-inflammatory (TNF-α, IL-17 and IFN-γ) signature to an Th2 and Treg anti-inflammatory (IL-10, IL-4 and TGF-β) one, as well as an increase in Treg cells (240, 246). Here, IL10 is linked to arthritic joint disease.