CD4 and infection: Previously reported nonsense variants include p.E228*, p.E381*, p.W387*, p.W688*, and p.C812*, with clinical–immunological features converging toward infancy-onset severe infections, near-complete loss of HLA-DR on APCs, marked CD4+ lymphopenia, and low IgG/IgA (IgM variably preserved) (23, 28–30).