H. pylori Activates IL-6-STAT3 Signaling in Human GC Cells: Potential Roles for ROS (128)IL-6 mediates epithelial-stromal interactions and promotes gastric tumorigenesis (129)RBMS1 promotes GC metastasis through autocrine IL-6/JAK2/STAT3 signaling (130)Berberine inhibits GC development and progression by regulating the JAK2/STAT3 pathway and downregulating IL-6 (131)VPS35 promotes GC progression through integrin/FAK/SRC signalling-mediated IL-6/STAT3 pathway activation in a YAP-dependent manner (132)MFGE8 promotes GC progression by activating the IL-6/JAK/STAT3 signaling (133). The gene discussed is PTK2; the disease is gastric cancer.