IFN-α sensitizes human GC cells to TRAIL-induced apoptosis via activation of the c-CBL-dependent MAPK/ERK pathway (304)IFN-α enhanced 5’-DFUR-induced apoptosis in GC cells by upregulation of TP expression, which is partially regulated by activation of ERK signaling (305). The gene discussed is TNFSF10; the disease is gastric cancer.