IL18R1 and gastric cancer: IL-23 promotes the migration and invasion of GC cells by inducing epithelial-to-mesenchymal transition via the STAT3 pathway (170)IL-23A can promoted GC cells growth by inducing the secretion of IL-17A in TME (171)IL23 receptor, as a key cytokine receptor gene in the important inflammatory IL-17/IL-23 axis, may contribute to GC predisposition (172)IL-8 and IL-23 induced an inflammatory response and leading to apoptosis, which can lead to carcinogenesis (173)