H. pylori with trx1 high expression promotes gastric diseases via upregulating the IL23A/NF-κB/IL8 pathway (139)CAFs-derived IL-8 plays important roles in chemoresistance, immunosuppression, and lymph node metastasis of GC (140)FAK/IL-8 axis promotes the proliferation and migration of GC cells (141)Cancer-Associated Fibroblast-Derived IL-8 Upregulates PD-L1 Expression in GC Through the NF-κB Pathway (142)Tumor-derived IL-8 facilitates lymph node metastasis of GC via PD-1 up-regulation in CD8 T cells (143). The gene discussed is CD274; the disease is stomach disorder.