Tipα secreted from H. pylori stimulates GC development by inducing TNF-α, an endogenous tumor promoter, through its interaction with nucleolin, a Tipα receptor (286)TNFα might activate TLR2-β-catenin-signaling in GC (287)The TNF-α/TNFR2 pathway increases the expression of Foxp3 and the production of TGF-β in T cells in the GC microenvironment (288)Oridonin suppresses GC SGC-7901 cell proliferation by targeting the TNF-alpha/androgen receptor/TGF-beta signalling pathway axis (289). The gene discussed is TNF; the disease is gastric cancer.