Eupafolin hinders cross-talk between GC cells and cancer-associated fibroblasts by abrogating the IL18/IL18RAP signaling axis (163)Inflammasome Adaptor ASC Suppresses Apoptosis of GC Cells by an IL18-Mediated Inflammation-Independent Mechanism (164)IL-18 produced by gastric epithelial cells protects against pre-neoplastic lesions in H. pylori infection in mice (165). The gene discussed is IL18RAP; the disease is gastric cancer.