GAS5 and systemic lupus erythematosus: Mechanistically, GAS5 was found to act through a ceRNA (competitive endogenous RNA) mechanism in T cells: it sponges miR-92a-3p, a microRNA that was elevated in SLE T cells, ßthereby preventing miR-92a from repressing its target E4BP4 (also known as NFIL3) (27, 52).