Conversely, forced over-expression of circ_003912 (77) or sustained knock-down of Tet2 via miR-142-3p (51) skewed the Th17/Treg balance, produced DNA hypermethylation at the FOXP3 CNS2 enhancer, and precipitated aggressive autoimmunity (51, 77). This evidence concerns the gene TET2 and Autoimmunity.