Systemic lupus erythematosus accounted for the largest share of papers (fifteen studies) and consistently centered on DNA hypomethylation or histone acetylation defects in CD4+ T cells (5, 11, 13, 18, 21, 27, 29, 43, 45, 48, 57, 59, 73, 74, 80). The gene discussed is CD4; the disease is systemic lupus erythematosus.