In disease research, LACC1 is closely associated with the pathogenic mechanisms of immune diseases (such as IBD and JIA), metabolic diseases (such as NAFLD and AS), infectious diseases (such as leprosy), neuropsychiatric disorders (such as sepsis-induced neuroinflammation and cognitive dysfunction), and fibrotic and degenerative diseases (such as autoimmune myocarditis and periarthritis of the shoulder). This evidence concerns the gene LACC1 and juvenile idiopathic arthritis.