Furthermore, LACC1 has been shown to be closely associated with various systemic diseases, including immune disorders such as inflammatory bowel disease (IBD) and juvenile idiopathic arthritis (JIA) (6, 11), metabolic conditions such as non-alcoholic fatty liver disease(NAFLD) and atherosclerosis (AS) (12, 13), infectious diseases like leprosy (14), and neurological disorders such as cognitive impairment following stroke (15). This evidence concerns the gene LACC1 and immune system disorder.