Through literature search, we summarized the molecular mechanisms of the cGAS‐STING pathway and its dysregulation in AD, emphasizing the integrated evidence linking cGAS‐STING to neuroinflammation, autophagy impairment, and neuronal death, as well as its interactions with aging, obesity, cardiovascular disease, and diabetes. Here, CGAS is linked to obesity due to melanocortin 4 receptor deficiency.