As indicated in Table 1, there was a significant rise in plasma levels of GFAP, p‐tau217, NfL, apolipoprotein E (APOE) ε4 prevalence, AV45‐PET positivity, and global AV45‐SUVR from the CN group to the MCI group and then to the dementia group, while hippocampal volumes significantly decreased. Here, NEFL is linked to dementia.