ACHE and Mental deterioration: Cognitive decline is intimately linked to cholinergic hypofunction and neurotransmitter dysregulation: diminished central acetylcholine (ACh) synthesis coupled with hyper-activated acetylcholinesterase (AChE) erodes cholinergic synaptic transmission, while the homeostatic balance between excitatory and inhibitory signals (glutamate vs. GABA) and monoaminergic tone (5-HT, DA, NE) is disrupted [48].