Accordingly, the present meta-analysis of 13 high-quality prospective cohorts conducted between 2019 and 2025 sought to (1) determine the pooled prognostic impact of IL-6, hs-CRP, and NLR on mortality and HF-related outcomes, (2) assess the consistency of these associations across key subgroups, and (3) evaluate their incremental value over traditional clinical and biochemical predictors. The gene discussed is CRP; the disease is hydrops fetalis.