RNASE2 and eosinophilic esophagitis: In fact, Lu et al. (2018) [33] reported that 15(S)-HETE may play a role as a biomarker when used in combination with other selective metabolites for EoE, such as eosinophil-derived neurotoxin (EDN), eotaxin-3, and IL-1, both for diagnosis and disease management.