Microbiology and labs reflected severe infection burden: Yamamoto reported urine culture positivity of 68.3%, bacteremia of 35.6%, and a median CRP of 16.1 mg/dL, with a median onset to drainage of 3 days and shock associated with older age and higher bacteremia rates [20]; Tambo found shock associated with positive blood cultures (59% vs. 18%) and non-E. coli pathogens (74% vs. 33%) [21]; and in the ED cohort, 58.3% had positive urine cultures [26]. This evidence concerns the gene CRP and infection.