PTPN11 and acute myeloid leukemia: Among the 27 patients with available cytogenetic or molecular data, 2 ALL cases were Philadelphia-positive, 1 AML had a normal karyotype, 3 had acute promyelocytic leukemia, and 20 patients with MDS and/or AML showed unfavorable cytogenetics such as −5, −7, del(17), 11q23 rearrangement, and chromosome 3 alterations and/or mutations in TP53, KMT2A, RAS, RUNX1, or PTPN11 (Table 3).