Indeed, current international diagnostic criteria—EASL 2017 [1] and AASLD 2018 [6]—define three key requirements: (i) evidence of cholestasis, typically alkaline phosphatase elevation; (ii) seropositivity for autoantibodies, mainly AMA-M2 or PBC-specific ANA; and (iii) histological findings of chronic nonsuppurative destructive cholangitis (CNSDC) and/or loss of interlobular bile ducts. Here, BTG3 is linked to primary biliary cholangitis.