The indices regularly adopted to discriminate the aggressiveness of MCL are: the Mantle Cell Lymphoma International Prognostic Index (MIPI) [2,3,4,5]; the morphologic features (classic vs. blastoid) [6,7,8,9]; and the evaluation of tumor kinetics (i.e., Ki67 expression). This evidence concerns the gene MKI67 and mantle cell lymphoma.