Apolipoprotein E plays a key role in lipid metabolism and transportation and its deficiency results in hyperlipidemia and atherosclerosis Similar results were obtained by Meester et al. using the SSTR2 antagonist 111In-DOTA-JR11 and single photon emission tomography, demonstrating high-lesion to background ratios in murine plaques [9]. This evidence concerns the gene SSTR2 and atherosclerosis.