In both cohorts, more than half of the events were grade 3 or higher, 22 of 36 (61%) in arm A and 19 of 30 (63%) in arm C. The most common AEs in arm A patients were diarrhea, increased liver enzymes (ALT and AST), fatigue, hypertension, nausea, anorexia, weight loss, decreased platelet count, stomatitis, and hypothyroidism. The gene discussed is GPT; the disease is hypertensive disorder.