Elevated CD71 in glioma/GBM then fuels an iron-dependent subnetwork (proliferation, metabolic plasticity, redox signaling), which in turn feeds back on HIF/NF-κB nodes via ROS and cytokine loops—creating self-reinforcing motifs that might support aggressiveness and treatment resistance [86,87,88]. Here, NFKB1 is linked to central nervous system cancer.