Furthermore, they used cholesterol efflux experiments and quantitative PCR to determine that iristectorigenin B enhances cholesterol efflux by inducing ATP binding cassette transporter A1(ABCA1) and ATP binding cassette subfamily G Member 1 (ABCG1), thereby demonstrating hypocholesterolemic effects without inducing hepatic steatosis [102]. The gene discussed is ABCA1; the disease is fatty liver disease.