Nana Yang et al. found that the C. florida Active Fraction (CFAF) significantly alleviates arthritis symptoms in adjuvant-induced arthritis (AA) rats, including reduced paw swelling, lowered arthritis index, and improved histopathological conditions, while also effectively decreasing serum levels of IL-1β, TNF-α, and IL-6. This evidence concerns the gene IL1B and arthritic joint disease.