XK and influenza: To date, anti-influenza (anti-flu) agents comprise therapeutics which generally are virus-directed agents targeting different steps of IAV replication cycle [8,9,10,11,12,13] as NA inhibitors (NAIs), ion channel blockers to interact the viral ion channel M2, viral polymerase inhibitors addressing their activity towards PA, PB1, and PB2 subunits, and HA inhibitors able to impair membrane fusion processes.