TXNRD1 and cancer: It is known that they show a weaker antioxidant effect than ETs [65]; they can activate phase II enzymes responsible for antioxidant activity and detoxification (thioredoxin reductase-1 or glutathione peroxidases) [1]; they have anti-inflammatory properties [13]; and thanks to the structural similarity to estrogens, they have anti-estrogenic/estrogenic properties [15] and anti-cancer activity [7,66].