Notably, this study demonstrates that NXC736 can modulate several pathogenic events in permanent ischemic stroke: (i) attenuates brain injury by improving neurological scores, reducing infarction volume, and cellular apoptosis; (ii) ameliorates BBB dysfunction and reduces brain edema; (iii) suppresses microglial activation and proliferation; (iv) attenuates upregulation of pro-inflammatory cytokine expression in injured brains; and (v) inhibits upregulation of NF-κB and activation of MAPK signaling pathways. Here, NFKB1 is linked to infarction.