Furthermore, a significant correlation was observed between the expression of CD8/CD3 and the absence of tumor spread through air spaces (STAS) (p = 0.001), with mean values of 1.36 ± 0.58 in cases without STAS and 3.38 ± 4.23 in cases with STAS (Figure 2B). This evidence concerns the gene CD8A and neoplasm.