GPR4 and ovarian carcinoma: GPR4, coupled predominantly to Gαs, has been shown to promote angiogenesis, endothelial cell permeability, and lymphatic metastasis in multiple solid tumours (including head and neck cancers and ovarian carcinoma), with its expression thought to contribute to tumour angiogenesis and immune evasion through endothelial cell activation and inflammatory mediator production [77].