This divergence in the glucose metabolism is directed by the oncogenic transcription factor HIF-1α (Hypoxia-Inducible Factor-1α), that besides the genes of the glycolytic pathway, also transcribes, among others, genes involved in angiogenesis (VEGF, vascular endothelial growth factor) and cell motility (HGF, hepatocyte growth factor), inflammation, and tumor microenvironment remodeling [157]. This evidence concerns the gene HGF and neoplasm.