When supercharged NK cells were adoptively transferred into humanized mice with solid tumors (oral, pancreatic, and melanoma), they notably slowed tumor growth, encouraged in vivo tumor differentiation, boosted peripheral NK cell function, enhanced immune cell infiltration into the tumor microenvironment, and increased CD8+ T cell levels in both tumor and peripheral tissues [102,165,170,178,179,180,181]. Here, CD8A is linked to neoplasm.