SOX2 and neoplasm: Sox2+ cell density (cells/mm2) was quantified across three anatomically defined regions: (i) Tumor bulk (TB): the central, densely cellular core of the tumor; (ii) Invasive margins, subdivided into the inner invasive margin (IIM), and the outer invasive margin (OIM) (Figure 1D); (iii) Contralateral corpus callosum (CC), a 1 mm-wide region extending from the longitudinal fissure into the CC of the hemisphere opposite to the tumor (Figure 1E).