It was recently demonstrated that wild-type P53 protein activity is a factual barrier against PanINs progression to PDAC [27] and that the wild-type TP53 gene could exert its tumor suppressor effect on the pancreatic cancer cell secretome, while secretome promotes cancer progression in TP53-mutated PDAC cells [28,29]. This evidence concerns the gene TP53 and familial pancreatic carcinoma.