The sdnRNA3, expressed in melanoma tumor-associated macrophages (TAMs), represses Nos2 gene transcription by recruiting the chromatin-remodeling regulator Mi-2β and depositing the repressive histone mark H3K27me3 at the gene promoter, thereby reducing chromatin accessibility and promoting an immunosuppressive tumor microenvironment [38]. Here, CHD4 is linked to neoplasm.