Building on their established intrinsic roles in tumor biology and tumor-stroma interactions, redox balance, and immune modulation, the significance of CSPG4, xCT, and TLR2 in OSA may be further understood in the context of the pervasive TP53 and RB1 alterations that define this tumor type [5,30]. This evidence concerns the gene TP53 and obstructive sleep apnea syndrome.