TLR2 and obstructive sleep apnea syndrome: To uncover new potential OSA vulnerabilities, here we explore the involvement of three appealing players—Chondroitin Sulfate Proteoglycan (CSPG)4, xCT, and Toll-like Receptor 2 (TLR2)—in the main hallmarks of OSA: proliferation and survival, metastasis and angiogenesis, and immune evasion.