GAAD had higher sensitivity than ultrasound plus AFP in most subgroups, including age (<65 years: 80.0% vs. 80.0%, p = 1.0; ≥65 years: 100% vs. 55.6%, p = 0.046), sex (men: 86.7% vs. 66.7%, p = 0.08; women: 100% vs. 75.0%, p = 0.32), liver disease etiology (MASLD: 87.5% vs. 75.0%, p = 0.32; ALD: 90.9% vs. 63.6%, p = 0.08), and Child Pugh class (Child Pugh A: 100% vs. 77.8%, p = 0.16; Child Pugh B-C: 80.0% vs. 60.0%, p = 0.16). The gene discussed is AFP; the disease is liver disorder.