On the other hand, in two tumor progression models using the MCF-10A.B2 cell line, which overexpresses ERBB2, and the MCF-10A.B2Cas cell line, which overexpresses the p130Cas protein, differential miRNA expression was observed in 3D cultures embedded in Matrigel® compared to 2D cultures. This evidence concerns the gene ERBB2 and neoplasm.