Independent of its chaperone function with tumor epitopes, HSP70 is also a potent activator of immune cells, prompting them to release cytokines such as TNF-α and thereby priming dendritic cells and macrophages/monocytes for APC functionality in an autologous positive feedback loop of TNF-α stimulation [23,28,30,39]. The gene discussed is HSPA4; the disease is neoplasm.