The cytotoxic functions of CTLs, such as granzyme B, perforin, IFN-γ, FasL (CD95L), and TNF-⍺, are elevated by induced hyperthermia, as is Fas receptor presentation on tumor cells (Figure 4b) [15,17,23,31,38,41,42,52,62]. The gene discussed is PRF1; the disease is neoplasm.