The molecular profile data of SCC-BG are derived mainly from studies of the vulvar cancer profile, which is logical given shared risk factors and pathology; within this framework, HPV-related squamous tumors tend to harbor PI3K/mTOR-axis lesions, including alterations in PTEN, PIK3CA, SOX2, FBXW7 and STK11 (all based on VSCC). Here, PIK3CA is linked to vulva cancer.