KLK3 and pachyonychia congenita: For example, in the GC-MS-based Models II and III reported by Huang et al. [40], the validation AUCs for predicting sPC were 0.93 and 0.88 for metabolic markers alone and 0.81 and 0.84 for five clinical factors alone (age, serum PSA, family history of PC, prior negative biopsy, and abnormal DRE), respectively, while the combination of the two achieved significantly higher AUCs of 0.95 and 0.93.