MKI67 and neoplasm: The following parameters were found to be statistically significant: major age at diagnosis (p = 0.020), atypical histotype (p = 0.010), advanced stage at diagnosis (p = 0.013), lymph node involvement at diagnosis (p = 0.006), presence of necrosis (p = 0.017), higher Ki-67 (p = 0.001), higher tumor grade (p = 0.002), higher mitotic count (p = 0.006), and presence of functional syndrome (p = 0.002).