ERBB2 and invasive breast carcinoma: We hypothesized that radiomics signatures from QUS spectral parametric images can be used to develop a robust multivariate model that offers a surrogate prediction for distinguishing intermediate-to-high-risk ODXRS from low-risk ODXRS, in a cohort of ER-positive (ER+), human epidermal growth factor receptor 2-negative (HER2−), lymph node negative (LN−) invasive breast cancers.