Later, Bai et al. provided critical translational evidence that AAV-mediated delivery of the NF1-GRD, particularly membrane-targeting variants fused with motifs such as the C-terminal 10 AA of HRAS domain (C10), the C-terminal 24 AA of KRAS4B (C24), and other similar RAS C-terminal domains, effectively suppressed aberrant RAS signaling and reduced tumor growth in NF1-associated MPNSTs [91]. Here, NF1 is linked to neoplasm.